发明名称 |
Promotion of adoptosis in cancer cells by co-administration of cyclin dependent kinase inhibitors and cellular differentiation agents |
摘要 |
The invention provides compositions and methods for promoting apoptosis of cancer cells, and methods for treating cancer. The compositions comprise cyclin dependent kinase inhibitor and an agent that induces cellular differentiation. The methods of promoting apoptosis of cancer cells involve the co-administration to the cancer cells of a cyclin dependent kinase inhibitor and an agent that induces cell differentiation. The method for treating cancer involves the co-administration of a cyclin dependent kinase inhibitor and an agent that induces cellular differentiation to a patient. Examples of cyclin dependent kinase inhibitors include histone deacetylase inhibitors, protein kinase C activators, retinoids, and Vitamin D3. |
申请公布号 |
AU8715701(A) |
申请公布日期 |
2002.03.26 |
申请号 |
AU20010087157 |
申请日期 |
2001.09.07 |
申请人 |
VIRGINIA COMMONWEALTH UNIVERSITY |
发明人 |
STEVEN GRANT;PAUL DENT;ROBERTO ROSATO;LEANNE CARTEE |
分类号 |
A61K31/19;A61K31/353;A61K31/59;A61K38/12 |
主分类号 |
A61K31/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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