| 摘要 |
A two-step process for the preparation of fluoroolefin compounds of formula IwhereinR is hydrogen or alkyl, and R<1 >is alkyl or cyclopropyl, or R and R<1 >are taken together with the carbon atom to which they are attached to form a cyclopropyl group;Ar is phenyl or naphthyl both of which are optionally substituted;Ar<1 >is phenoxyphenyl, biphenyl, phenyl, benzylphenyl, or benzoylphenyl, all of which may be optionally substituted,comprising reacting fluorobromoolefin compounds of formula IIwith organozinc compounds of formula III or IVin the presence of a palladium catalyst and a solvent,which compounds of formula II are obtained by reacting aldehyde compounds of formula Vwith(a) fluorotribromomethane,(b) a tri(substituted)phosphine or a hexaalkylphosphoramide or a mixture thereof, and(c) zinc,in the presence of a solvent,compounds of formula II. |
