Antibacterials mutilins

摘要

A compound of formula (I) wherein R and R₂ together with the nitrogen atom to which they are attached form pyrrolidinyl or piperidinyl, R₁ is a group of formula (II) R₃ and R'₃ are hydrogen, deuterium or halogen, R₄, R₅ and R₁₀ are independently of each other hydrogen or alkyl, R₆, R₇ and R₈ are hydrogen or deuterium; R₉ is amino, alkyl, aryl, heterocyclyl or mercapto; and, if X is oxygen, R₉ is additionally hydrogen; R'₁₀ is alkyl, X is sulphur, oxygen, NR₁₀, or N+(R'₁₀)₂; Y is sulphur or oxygen, and m is 0, 1 or 2; with the proviso that, when R and R₂ together with the nitrogen atom to which they are attached form piperidinyl, m is O, Y is S and Y is attached in position 3 of said piperidine ring, that group of formula (I) which is attached to the piperidine ring via the residue Y is either in the (S)-configuration or in the (R)-configuration, preferably in the (S) -configuration which is e.g. useful as antimicrobial, antibacterial.