| 发明名称 |
pseudo-native chemical ligation |
| 摘要 |
The present invention concerns methods and compositions for extending the technique of native chemical ligation of a wider range of peptides, polypeptides, other polymers and other molecules via an amide bond (see FIG. 1 ). The invention further provides methods and uses for such proteins and derivatized proteins. The invention is particularly suitable for use in the synthesis of optionally polymer-modified, synthetic bioactive proteins, and of pharmaceutical compositions that contain such proteins. |
| 申请公布号 |
AU7338801(A) |
申请公布日期 |
2002.03.22 |
| 申请号 |
AU20010073388 |
申请日期 |
2001.07.12 |
| 申请人 |
GRYPHON SCIENCES |
发明人 |
STEPHEN B.H. KENT;PAOLO BOTTI;DONALD W. LOW;JAMES A. BRADBURNE;CHRISTIE L. HUNTER;SHIAH-YUN CHEN;SONYA CRESSMAN;GERD KOCHENDOERFER |
| 分类号 |
A61K38/00;A61K38/02;A61K38/22;A61K47/34;A61K47/42;A61K47/48;A61P7/00;A61P7/06;A61P9/10;A61P11/02;A61P11/06;A61P17/00;A61P19/02;A61P29/00;A61P31/12;A61P37/06;A61P37/08;A61P43/00;C07K1/00;C07K1/06;C07K14/47;C07K14/505;C07K14/52;C07K17/08;C07K19/00 |
主分类号 |
A61K38/00 |
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