| 摘要 |
Controlled-release pharmaceuticals are prepared by mixing starting materials and a process medium in a reactor to form a supercritical fluid slurry. The starting materials include a biologically active ingredient and a polymer. The process medium preferably is carbon dioxide which is supplied to the reactor in a supercritical state or which is heated and pressurized in the reactor to attain a supercritical state. After mixing for a period of time, the slurry either is left in the reactor or is discharged into a receiving vessel. The process medium is separated from the other materials and removed, leaving behind finely divided particles. The particles comprise porous particles of polymer that are infused with the biologically active ingredient. The finely divided particles can be incorporated into tablets, capsules, or the like for ingestion by patients. |
