| 摘要 |
<p>A composition for medicated chewing gums comprising particles of an active principle dispersed in the gum, which are coated with a mixture of a hydrosoluble element and a water insoluble element, is new. The coating allows a gradual and controlled release of the principle. An independent claim is also included for a process for obtaining the medicated chewing gum, which comprises: (a) heating the insoluble element until a complete solution is obtained; (b) mixing the soluble element with the active principle; (c) pouring the mixture in the solution of the insoluble element; (d) cooling the mixture obtained and mixing with the gum base and the additives; and (e) pressing at no higher than room temperature. ACTIVITY : Antismoking. Three tablets of the invention comprising 2 mg nicotine were administered, respectively, to 3 adult subjects and the plasmatic levels of nicotine were determined by taking blood samples. The results showed that nicotine reached high plasmatic levels within 40-75 minutes confirming good bioavailability and strong absorption of the active principle when the composition is used. MECHANISM OF ACTION : None given.</p> |
