Propanoic acid derivatives

摘要

Propanoic acid derivatives of formula (1) are described:Ar-X1-Ar1-Z-R (1)in which Ar is a nitrogen base containing group; X1 is linker atom or group; Ar1 is an optionally substituted 5- or 6-membered nitrogen-containing aromatic or non-aromatic monocycle; Z is a group -CH(R13)CH2- [in which R13 is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group], -C(R12a)(R13)-CH(R12b)- [in which R12a and R12b together with the carbon atoms to which they are attached form a C3-7cycloalkyl group] or C(R13)=CH-; R is a carboxylic acid (-CO2H) or a derivative or biostere thereof; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of alphav integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.