NUCLEIC ACID MOLECULES ENCODING A POLY(ADP-RIBOSE) POLYMERASE

摘要

Disclosed are nucleic acid molecules encoding a protein having poly(ADP-ribose) polymerase (PARP) activity as well as the encoded protein. Furthermore, the invention describes expression vectors, host cells, antibodies, pharmaceutical compositions and methods for treating disorders associated with aberrant regulation of cellular behaviour. Finally, screening methods are described for compounds that act as agonist or antagonist of the protein having PARP activity.