摘要 |
This invention describes novel pyrazole compositions comprising a pharmaceutically acceptable carrier and a compound of formula (V) wherein Z1 is N, CRa, or CH, and Z2 is N or CH, provided one of Z1 and Z2 is nitrogen; G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidiny l, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substitutents independently selected from -R1; Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selecte d from T-R3, or Rx and Ry are taken together with their intervening atoms to form a fused ring; and R1, R2, R2', R3, and T are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such a s cancer, diabetes and Alzheimer's disease.
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申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
GOLEC, JULIAN;BINCH, HAYLEY;PATEL, SANJAY;KAY, DAVID;PIERCE, ALBERT;DAVIES, ROBERT;KNEGTEL, RONALD;WANNAMAKER, MARION;FORSTER, CORNELIA;BEBBINGTON, DAVID;CHARRIER, JEAN-DAMIEN;LI, PAN |