Verfahren zur Messung der Aktivität von Gerinnungsfaktor XIIIa

摘要

The invention relates to a method for measuring the activity of the blood clotting factor XIIIa. The aim of the invention is to provide a method for measuring the activity of FXIIIa which is simple to carry out and which is also suitable for use with testing systems that have a high throughput. It was found that activated FXIII influences the light transmitting power of fibrin clots. Fibrinogen is caused to clot with a fibrinogen-splitting enzime. The change in the light transmitting power of the samples according to the concentration of FXIIIa present is registered and is used as a measure of the activity of FXIIIa. The inventive method can be used especially for screening for FXIIIa inhibitors.