Multipartikuläre Arzneiform und Verfahren zu ihrer Herstellung

摘要

The invention relates to a multiparticulate pharmaceutical dosage form, produced from particles compressed with conventional binding agents. Said particles contain a pharmaceutical active ingredient and are covered with a gastric-juice resistant coating consisting of a (meth)acrylate copolymer that comprises 40 to 60 wt.- % methacryl acid and 60 to 40 wt.- % ethylacrylate. Said dosage form is characterized in that the coating contains more than 15 and up to 50 wt.- % of the plasticizer propylene glycol in relation to the (meth)acrylate copolymer and that the particle fraction of the pharmaceutical dosage form constitutes 35-90 wt.- % for an application quantity of the coating in excess of 15 and up to 38 wt.- % in relation to the particle weight. The invention also relates to the production method and to the corresponding use of propylene glycol as a plasticizer.