发明名称 |
ENZYMATIC RESOLUTION OF ARYL- AND THIO-SUBSTITUTED ACIDS |
摘要 |
Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer, (I), wherein Ar is C6 or C10 aromatic group that can be substituted with H, C1 to C6 alkyl, trifluoromethyl or halo, R5 is halo or -S-R1, wherein R1 is H or acetyl, and R2 is H or C1 to C6 alkyl, the method comprising: reacting a compound of formula (I) wherein the compound i s an ester whereby R2 is C1 to C6 alkyl with a lipase derived from Mucor meihe i to stereoselectively hydrolyze the ester bond to produce an acid; and isolating the acid, wherein the reaction is conducted in a solvent comprisin g 80 % to 98% v/v % organic phase and a residue of water phase (which can be buffered). |
申请公布号 |
CA2422466(A1) |
申请公布日期 |
2002.03.21 |
申请号 |
CA20012422466 |
申请日期 |
2001.09.12 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
ZHAO, SHANNON X.;ZHU, JINGYANG;SKONEZNY, PAUL M.;WHITE, BRENDA J.;YOU, LI |
分类号 |
C07B55/00;C07C67/343;C07C327/08;C12P7/40;C12P7/62;C12P11/00;C12P41/00;C12R1/785 |
主分类号 |
C07B55/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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