摘要 |
Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer, (I), wherein Ar is C6 or C10 aromatic group that can be substituted with H, C1 to C6 alkyl, trifluoromethyl or halo, R5 is halo or -S-R1, wherein R1 is H or acetyl, and R2 is H or C1 to C6 alkyl, the method comprising: reacting a compound of formula I wherein the compound is an ester whereby R2 is C1 to C6 alkyl with a lipase derived from <i>Mucor meihei</i> to stereoselectively hydrolyze the ester bond to produce an acid; and isolating the acid, wherein the reaction is conducted in a solvent comprising 80 % to 98% v/v % organic phase and a residue of water phase (which can be buffered). |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;ZHU, JINGYANG;YOU, LI;WHITE, BRENDA, J.;ZHAO, SHANNON, X.;SKONEZNY, PAUL, M. |
发明人 |
ZHU, JINGYANG;YOU, LI;WHITE, BRENDA, J.;ZHAO, SHANNON, X.;SKONEZNY, PAUL, M. |