发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITION OF HIV-1 INFECTION |
摘要 |
This invention provides a composition which comprises an admixture of three compounds, wherein: a) one compound is an antibody which binds to a CCR5 receptor; b) one compound retards attachment of HIV-1 to a CD4+ cell by retarding binding of HIV-1 gp120 envelope glycoprotein to CD4 on the surface of the CD4+ cell; and c) one compound retards gp41 from adopting a conformation capable of mediating fusion of HIV-1 to a CD4+ cell by binding noncovalently to an epitope on a gp41 fusion intermediate; wherein the relative mass ratio of any two of the compounds in the admixture ranges form about 100:1 to about 1:100, the composition being effective to inhibit HIV-1 infection of the CD4+ CELL. This invention also provides a method of inhibiting HIV-1 infection of a CD4+ cell which comprises contacting the CD4+ cell with an amount of the composition of the subject invention effective to inhibit HIV-1 infection of the CD4+ cell so as to thereby inhibit HIV-1 infection of the CD4+ cell. |
申请公布号 |
WO0222077(A2) |
申请公布日期 |
2002.03.21 |
申请号 |
WO2001US28756 |
申请日期 |
2001.09.14 |
申请人 |
PROGENICS PHARMACEUTICALS, INC. |
发明人 |
OLSON, WILLIAM, C.;MADDON, PAUL, J. |
分类号 |
A61K38/00;A61K38/16;A61K39/395;A61K45/06;A61P31/18;C07K14/16;C07K16/28 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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