| 发明名称 |
METHODS AND COMPOSITIONS RELATING TO HYDROGEN PEROXIDE AND SUPEROXIDE PRODUCTION BY ANTIBODIES |
| 摘要 |
The invention relates generally to the field of immunology. More specificall y, the invention relates the finding that antibodies can generate superoxide an d hydrogen peroxide from singlet oxygen. Accordingly, methods and compositions able to increase or decrease oxidative stress are provided. Also provided ar e screening assays to identify agents that modulate the ability of a antibody to generate superoxide and hydrogen peroxide. Such agents can be used therapeutically to treat patients in need. Further, the invention provides methods to use antibodies in immunoassays.
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| 申请公布号 |
CA2422586(A1) |
申请公布日期 |
2002.03.21 |
| 申请号 |
CA20012422586 |
申请日期 |
2001.09.17 |
| 申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
WENTWORTH, PAUL;JONES, LYN H.;LERNER, RICHARD A.;WENTWORTH, ANITA D.;JANDA, KIM D. |
| 分类号 |
G01N33/50;A61K9/127;A61K31/05;A61K31/19;A61K31/352;A61K31/355;A61K31/375;A61K31/385;A61K31/4045;A61K35/12;A61K35/76;A61K38/06;A61K38/44;A61K38/45;A61K39/395;A61K45/00;A61K45/06;A61K48/00;A61M35/00;A61N5/06;A61P1/00;A61P1/04;A61P9/00;A61P9/10;A61P9/12;A61P11/00;A61P13/00;A61P13/08;A61P13/12;A61P15/00;A61P17/02;A61P19/02;A61P21/00;A61P25/00;A61P25/16;A61P25/28;A61P25/32;A61P25/34;A61P29/00;A61P31/18;A61P35/00;A61P35/02;A61P37/02;A61P37/04;A61P39/06;C07K16/32;C12N15/09;G01N33/15;G01N33/53;G01N33/543;(IPC1-7):A61K31/405;A61K38/43;G01N33/533;G01N33/563;C07K14/725 |
主分类号 |
G01N33/50 |
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