摘要 |
This invention describes novel pyrazole compounds of formula III:wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R<x> and R<y> are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered carbocyclo ring; and R<2> and R<2'> are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
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申请人 |
VERTEX PHARMACEUTICALS INCORPORATED;DAVIES, ROBERT;BEBBINGTON, DAVID;BINCH, HALEY;KNEGTEL, RONALD;GOLEC, JULIAN M.C.;PATEL, SANJAY;CHARRIER, JEAN-DAMIEN;KAY, DAVID;DAVIES, ROBERT |
发明人 |
DAVIES, ROBERT;BEBBINGTON, DAVID;BINCH, HALEY;KNEGTEL, RONALD;GOLEC, JULIAN M.C.;PATEL, SANJAY;CHARRIER, JEAN-DAMIEN;KAY, DAVID;DAVIES, ROBERT |