PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS

摘要

This invention describes novel pyrazole compositions comprising a pharmaceutically acceptable carrier and a compound of formula VIII, wherein Z1 is N or C-R9, Z2 is N or CH, and Z3 is N or C-Rx, provided that one of Z?1 and Z3¿ is nitrogen; G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substitutents independently selected from -R1; Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; and R?x, R1, R2, R2', R3 and R9¿ are as described inthe specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.