METHOD TO INDUCE THE TH1 IMMUNE RESPONSE

摘要

The present invention relates to a method to induce the CD4+ Th1 immune response, eventually combined with a repression of the Th2 mediated activities, comprising the administration of an IgG isotype antibody which is not an IgG1 isotype antibody. Preferentially said antibody is an IgG2a and/or IgG2b isotype anti-allergen antibody. The shift from a Th2 response towards a mixed Th1/Th2 response is particularly useful in the treatment of diseases such as asthma.Because the method described corrects the immuno-pathological cause of the disease, this is the polarised Th2 response against allergen, rather than its consequences, a sustained cure from asthma can be achieved instead of a transient reduction of symptoms.