| 摘要 |
<p>Method for producing a human monoclonal antibody, said method comprising: Providing a library of binding molecules, the binding domain of which consists essentially of human heavy chain variable fragments in a functional format, selecting from said library at least one heavy chain variable fragment having a desired affinity, and inserting a nucleic acid encoding said heavy chain variable fragment into a nucleic acid encoding the complementary part of at least a heavy chain of said human monoclonal antibody, allowing for expression of the resulting heavy chain and for assembly of said heavy chain with a desired light chain, and producing a human monoclonal antibody. Said functional format is due to fusion to a phage-associated structural protein.</p> |
