FUNCTIONALIZED POLYAMINE CHELANTS AND RHODIUM COMPLEXES THEREOF FOR CONJUGATION TO ANTIBODIES

摘要

A group of functionalized polyamine chelants that form complexes with rhodium are disclosed. The rhodium complexes can be attached to an antibody or antibody fragment and used for therapeutic or diagnostic purposes. The chelant has the formula: (See formula I) In the formula R is a 2-10 C alkylene, R' is H or 1-10 alkylene, X and X' each represent hydrogen or together can form a 2-10 C alkylene bridging group, n is 0 or 1, y is 1 to 3 and L is a linker group which allows for attachment to the antibody or fragment thereof.