MIXED SPECIFICITY FUSION PROTEINS

摘要

Mixed specificity fusion proteins capable of binding to cellular adhesion molecules have been produced. The fusion pro- teins contain a polypeptide region, such as an IgG constant region, operatively attached to at least two binding regions each of which corresponds to either an extracellular domain of a cell surface recept or for cellular adhesion molecules, or a variable re- gion of an antibody directed to a cellular adhesion molecule. A method of inhibiting inflammation in a patient is disclosed in which the present fusion proteins are administered to a patient to inhibit t he attachment of inflammatory cells to vascular endo- thelium. A method of inhibiting metastasis is disclosed in which the present fusion proteins are administered to a patient to inhi- bit the metastasis of responsive tumor cells.