NON-IMMUNOSUPPRESSING [gamma-HYDROXY-METHYLLEUCINE 4]CYCLOSPORINE A, HAIR-GROWTH STIMULATING AGENT AND SKIN CARE PREPARATION CONTAINING THE AGENT

摘要

PROBLEM TO BE SOLVED: To provide a non-immunosuppressing cyclosporine A derivative keeping hair-growth stimulation effect while decreasing the immunosuppressant action to an extent. SOLUTION: This invention relates to a pharmaceutical composition using non-immunosuppressing [γ-hydroxy-methylleucine4]cyclosporine A produced by adding hydroxyl group to theγ-carbon of 4-methylleucine of cyclosporine A by microbial metabolic process and having excellent hair growth promoting effect and to a method for preventing falling-out of hair and stimulating the hair growth.