NEW NUCLEOTIDE ANALOG AND METHOD FOR PRODUCING THE SAME

摘要

PROBLEM TO BE SOLVED: To obtain a new and useful NTP analog having a structural similarity to nucleoside triphosphate(NTP) and a function of electrophilicity, and to provide a method for producing the same, more concretely, a new and useful APT analog having a structural similarity to adenosine 5'-triphosphate (ATP) and having a function of electrophilicity and to provide a method for producing the same. SOLUTION: This nucleotide analog is obtained by substituting a phosphorus atom at theγ-position (orδ-position) of a nucleotide containing 3 or 4 phosphate groups at the 5' position of a saccharide with a boron atom and an oxygen atom between theγ-position andβ-position (or between theδ-position and theγ-position) with a CF2 group or a CH2 group. This method for producing the nucleotide analog is provided. This specific intermediate in the method for producing the nucleotide analog is provided. This method for producing the intermediate is provided.