Polo box therapeutic compositions, methods, and uses therefor

摘要

The amino acid sequence of a polo box is provided based on residue-by-residue mutation and analysis of phenotype. Additional polo boxes in the polo kinase protein located between the first polo box and the carboxy terminal are provided. Compositions and methods are provided for obtaining inhibitors of polo box function, for use as therapeutics for treatment of cancer, infection a fungi, protozoans, and helminths, for arthropod infestation of a subject, and for treatment of tumors.