METHOD FOR DETECTING SENESCENT CELLS USING CAVEOLIN, COMPOSITION FOR INDUCING SENESCENT STATE OF CELLS AND METHOD FOR INDUCING SENESCENT STATE OF CELLS

摘要

PURPOSE: Provided is a method for detecting senescent cells particularly by using caveolin. Also, provided is a composition inducing a senescent state of cells and containing an expression vector for eukaryote into which caveolin gene is inserted. Further, provided is a method for inducing a senescent state of cells by using the composition. CONSTITUTION: The method for detecting senescent cells in mammals is characterized by measuring the increase of caveolin protein being in mammal cells, with western blotting analysis. The composition inducing senescent state of mammal cells contains an expression vector for eukaryote as an active ingredient. The caveolin gene has an amino acid-coding sequence of SEQ ID NO:2. The senescent state of mammal cells is induced by transforming them with the vector containing caveolin gene.