DERIVATIVES OF CYCLIC THIOCARBAMATES, PHARMACEUTICAL COMPOSITION INCLUDING NOTED DERIVATIVES OF CYCLIC THIOCARBAMATES AND ACTIVE INGREDIENTS OF MEDICINES AS MODULATORS OF PROGESTERONE RECEPTORS

摘要

In this invention a compounds are described which are agonists of progesterone receptors and have structures (I) or (II), where R1 and R2 û is independent substituents from group consisting of H, possibly substituted C1 û C6 alkyl, alkenyl, alkinyl or alkinyl groups, C3 û C8 cycloalkyl, aryl, substituted aryl or heterocyclic groups, or CORA or NRBCORA, or R1 and R2 alloyed and create spirocyclic alkyl or alkenyl ring with possibility of substitution with 3-8 members or spirocyclic ring, including 1-3 heteroatoms from O, S and N; RA is selected from H, amino or possibly substituted C1 û C3 alkyl, aryl, C1 û C3 alkoxy or C1 û C3 aminoalkyl groups; R3 - is H, C1 û C3 alkyl or substituted C1 û C3 alkyl; R3 - is H, OH, NH2, CORC or possibly substituted C1 û C6 alkyl, C3 û C6 alkenyl or alkinyl groups; RC is selected from H, possibly substituted C1 û C3 alkyl, aryl, C1 û C3 alkoxy or C1 û C3 aminoalkyl groups; Q1 - is S, NR7 or CR8R9; R5 may be trisubstituted benzene ring or substituted heterocyclic ring with 5 or 6 members with 1, 2 or 3 ring heteroatoms, selected from group O, S, SO, SO2 or NR6; or their pharmaceutically suited salts, and methods of use of these compounds for contraception and healing of diseases connected with progesterone.