BICYCLIC ENAMIDE DERIVATIVES BEING INTEGRIN INHIBITORS

摘要

Enamide derivatives of formula (1) are described: (1) wherein R1 is a group Ar<1>L<2>Ar<2>Alk- in which Ar<1> is an optionally substituted aromatic or heteroaromatic group, L2 is a covalent bond or a linker atom or group, Ar<2> is an optionally substituted arylene or heteroarylene group and Alk is a chain -CH2-CH(R)-, -CH=C(R)- or formula (II) in which r is a carboxylic acid (-CO2H) or a derivative or biostere thereof; R<2> is a hydrogen atom or a C1-6alkyl group; X is an O or S atom or the group NR<30> group; j and k is each zero or the integer 1 or 2 provided that the sum of j and k is zero or the integer 1 or 2. Cy<1> is an optionally substituted cycloaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; and the salts, solvantes, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders, or disorders including the inappropriate growth or migration of cells.