| 摘要 |
The present invention relates to the discovery of gene and its sequence variation associated with lipid disorder and cancer. The present invention also relates to the study of metabolic pathways and cellular mechanisms to identify other genes, receptors, and relationships that contribute to lipid disorder and cancer. The present invention also relates to germline or somatic sequence variation and its use in the diagnosis and prognosis of predisposition to lipid disorder and cancer. The present invention also provides primers or probes specific for the detection and analysis of such sequence variation. The present invention also relates to methods to screen drugs for inhibition or restoration of gene function as an anti-lipid disorder or anti-cancer therapy. Finally, the present invention relates to other anti-lipid disorder or anti-cancer therapies, such as gene therapy, protein replacement therapy, etc. |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;BODNAR, JACKIE, S.;CASTELLANI, LAWRENCE, W.;CHATTERJEE, AUROBINDO;DE JONG, PIETER;LUSIS, ALDONS, J.;OHMEN, JEFF;ROSS, DAVID;TAFURI, SHERRIE;WU, CHENYAN |
发明人 |
BODNAR, JACKIE, S.;CASTELLANI, LAWRENCE, W.;CHATTERJEE, AUROBINDO;DE JONG, PIETER;LUSIS, ALDONS, J.;OHMEN, JEFF;ROSS, DAVID;TAFURI, SHERRIE;WU, CHENYAN |
