发明名称 |
SUBSTITUTED OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS |
摘要 |
The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications. |
申请公布号 |
WO0220479(A1) |
申请公布日期 |
2002.03.14 |
申请号 |
WO2001US26423 |
申请日期 |
2001.08.23 |
申请人 |
GLAXO GROUP LIMITED;KUYPER, LEE, FREDERICK;LACKEY, KAREN, ELIZABETH;WOOD, III, EDGAR, RAYMOND |
发明人 |
KUYPER, LEE, FREDERICK;LACKEY, KAREN, ELIZABETH;WOOD, III, EDGAR, RAYMOND |
分类号 |
A61K31/404;A61K31/433;A61K31/4439;A61P25/04;A61P29/00;A61P29/02;A61P35/00;A61P43/00;C07D209/34;C07D209/40;C07D401/12;C07D417/12 |
主分类号 |
A61K31/404 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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