发明名称 |
HIGH-THROUGHPUT FORMATION, IDENTIFICATION, AND ANALYSIS OF DIVERSE SOLID-FORMS |
摘要 |
The invention concerns arrays of solid-forms of substances, such as compounds and rapid-screening methods therefor to identify solid-forms, particularly of pharmaceuticals, with enhanced properties. Such properties include improved bioavailability, solubility, stability, delivery, and processing and manufacturing characteristics. The invention relates to a practical and cost-effective method to rapidly screen hundreds to thousands of samples in parallel. The invention further provides methods for determining the conditions and/or ranges of conditions required to produce crystals with desired compositions, particle sizes, habits, or polymorphic forms. In a further aspect, the invention provides high-throughput methods to identify sets of conditions and/or combinations of components compatible with particular solid-forms, for example, conditions and/or components that are compatible with advantageous polymorphs of a particular pharmaceutical. |
申请公布号 |
WO0151919(A9) |
申请公布日期 |
2002.03.14 |
申请号 |
WO2001US00531 |
申请日期 |
2001.01.08 |
申请人 |
TRANSFORM PHARMACEUTICALS, INC.;LEVINSON, DOUGLAS;CIMA, MICHAEL, J.;LEMMO, ANTHONY, V.;GALAKATOS, NICHOLAS;PUTNAM, DAVID, A. |
发明人 |
LEVINSON, DOUGLAS;CIMA, MICHAEL, J.;LEMMO, ANTHONY, V.;GALAKATOS, NICHOLAS;PUTNAM, DAVID, A. |
分类号 |
G01N23/04;B01J19/00;B01L3/00;C07B61/00;C07B63/00;C07C227/42;C07C229/08;C12Q1/00;C30B7/00;C40B30/04;C40B40/06;C40B40/10;C40B40/12;C40B60/14;G01N1/28;G01N1/36;G01N13/14;G01N13/16;G01N21/03;G01N21/23;G01N21/35;G01N21/65;G01N23/20;G01N23/225;G01N24/08;G01N33/15;G01N33/48;G01N33/50;G01N33/68;G01N37/00;G06F19/00 |
主分类号 |
G01N23/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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