| 发明名称 |
PSEUDO-NATIVE CHEMICAL LIGATION |
| 摘要 |
The present invention concerns methods and compositions for extending the technique of native chemical ligation of a wider range of peptides, polypeptides, other polymers and other molecules via an amide bond (see Figu re 1). The invention further provides methods and uses for such proteins and derivatized proteins. The invention is particularly suitable for use in the synthesis of optionally polymer-modified, synthetic bioactive proteins, and of pharmaceutical compositions that contain such proteins.
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| 申请公布号 |
CA2412279(A1) |
申请公布日期 |
2002.03.14 |
| 申请号 |
CA20012412279 |
申请日期 |
2001.07.12 |
| 申请人 |
GRYPHON THERAPEUTICS, INC. |
发明人 |
KOCHENDOERFER, GERD;CRESSMAN, SONYA;KENT, STEPHEN B. H.;CHEN, SHIAH-YUN;HUNTER, CHRISTIE L.;BRADBURNE, JAMES A.;BOTTI, PAOLO;LOW, DONALD W. |
| 分类号 |
A61K38/00;A61K38/02;A61K38/22;A61K47/34;A61K47/42;A61K47/48;A61P7/00;A61P7/06;A61P9/10;A61P11/02;A61P11/06;A61P17/00;A61P19/02;A61P29/00;A61P31/12;A61P37/06;A61P37/08;A61P43/00;C07K1/00;C07K1/06;C07K14/47;C07K14/505;C07K14/52;C07K17/08;C07K19/00;(IPC1-7):A61K38/02;C07K2/00;C07K1/02;A61K38/18;A61K38/19;A61K38/20;A61K38/21;A61K38/27;C07K14/475;C07K14/525;C07K14/535;C07K14/54;C07K14/555;C07K14/575 |
主分类号 |
A61K38/00 |
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