| 摘要 |
<p>The invention provides methods of delivering an antigen to an Class I or Class II MHC receptors to induce immunity against the antigen in a subject having a disease. This invention invention also provides methods of delivering an antigen to an Class II or class I MHC receptor to supress immunity against the antigen in a subject having a disease. The ligand-binding APCs to bind to the ligand-coated Ag/ATP-filled particles and APC phagolysosomes to ingest the ligand-coated Ag(ATP-filled particles to facilitate transfer of the ingested antigen from the phagolysosomes into cytoplasm such that the angigen is delivered to a Class II MHC receptor and is expressed on the surface of the APCs (Ag-APCs), d) incubating the Ag-APCs of step (c) with lymphocytes previously removed from the subject having the disease; and e) administering the incubated lymphocytes of step (d) to the subject so as induce Class II MHC presentation and elicit suppressor T-lymphocytes so to supress immunity against the angiten in the subject.</p> |
