发明名称 |
DIHYDROXY OPEN-ACID SALT OF SIMVASTATIN |
摘要 |
The instant invention provides methods and pharmaceutical compositions for inhibiting HMG-CoA reductase, as well as for treating and/or reducing the ri sk for diseases and conditions affected by inhibition of HMG-CoA reductase, comprising orally administering a therapeutically effective amount of a crystalline hydrated form of the calcium salt of dihydroxy open acid simvastatin to a patient in need of such treatment. Methods for making the calcium salt of dihydroxy open acid simvastatin are also provided.
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申请公布号 |
CA2421018(A1) |
申请公布日期 |
2002.03.14 |
申请号 |
CA20012421018 |
申请日期 |
2001.09.05 |
申请人 |
MERCK & CO., INC. |
发明人 |
VEGA, JOSE M.;VARSOLONA, RICHARD J.;GRABAOWSKI, EDWARD J. J.;TILLYER, RICHARD D.;REIDER, PAUL J.;WENSLOW, ROBERT M.;XU, FENG |
分类号 |
A61K9/52;A61K9/00;A61K9/28;A61K31/22;A61K31/366;A61P3/06;A61P9/10;A61P43/00;C07C67/28;C07C67/52;C07C67/56;C07C69/30;C07D309/30;(IPC1-7):C07C69/30 |
主分类号 |
A61K9/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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