| 发明名称 |
Metabolites of ecteinascidin 743 formed by human cytochrome CYP3A4 |
| 摘要 |
The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as "ETM" followed by a numeric value which represents the approximate molecular weight. Three compounds have been identified to date, namely ETM 305, ETM 775 and ETM 204. The structures of these ecteinascidin metabolites are as follows:
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| 申请公布号 |
US2002032326(A1) |
申请公布日期 |
2002.03.14 |
| 申请号 |
US20010971852 |
申请日期 |
2001.10.03 |
| 申请人 |
RINEHART KENNETH L.;MORALES JOSE J.;REID JOEL;REYMUNDO ISABEL;FLORIANO PABLO;GARCIA GRAVALOS LOLA |
发明人 |
RINEHART KENNETH L.;MORALES JOSE J.;REID JOEL;REYMUNDO ISABEL;FLORIANO PABLO;GARCIA GRAVALOS LOLA |
| 分类号 |
A61K31/357;A61K31/36;A61K31/39;A61K31/47;A61K31/472;A61K31/4747;A61K31/4995;A61K35/02;A61P35/00;C07D217/10;C07D217/24;C07D317/44;C07D317/64;C07D317/66;C07D327/02;C07D411/14;C07D491/14;C07D497/22;C07D515/22;(IPC1-7):C07D487/22 |
主分类号 |
A61K31/357 |
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