BENZOIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

摘要

Benzoic acid derivatives represented by the following general formula (I) and nontoxic salts thereof wherein R1 represents COOH, COOR6, etc.; A and B each represents a carbon ring or a heterocycle; R2 represents alkyl, alkenyl, alkynyl, etc.; R4 represents alkyl, cycloalkyl, etc.; and R5 represents a carbon ring or a heterocycle. The compounds represented by the general formula (I) strongly bind to PGE¿2? receptors, in particular, subtypes EP3 and/or EP4 and exert an antagonism, which makes them useful in preventing and/or treating diseases such as pain, allergy, Alzheimer and cancer.