| 摘要 |
<p>A method of screening a drug capable of inhibiting the expression of an OSF-2 gene or the production or function of the protein, and remedies for heart failure having these effects are provided. By monitoring the expression and variation of the above gene or the production of the protein, a useful method of diagnosing heart failure can be provided. Moreover, a transgenic animal in which the OSF-2 gene is forcedly expressed, and a method of examining changes in the gene expression or the protein production in association with the progress of the pathological conditions of heart failure or the functions of various genes or proteins by using such a transgenic animal are provided.</p> |
