发明名称 |
METHOD FOR THE IMPROVEMENT OF ISLET SIGNALING IN DIABETES MELLITUS AND FOR ITS PREVENTION |
摘要 |
<p>The present invention discloses a method for therapeutically treating mammals, including but not limited to humans, to increase the relative insulin producing performance of endogenous pancreatic beta -cells and to cause differentiation of pancreatic epithelial cells into insulin producing beta -cells. Oral administration of a DP IV inhibitor causes the active form of GLP-1 to be preserved longer under physiological conditions. The extended presence of GLP-1, in particular in the pancreatic tissue facilitates differentiation and regeneration of the beta -cells already present that are in need of repair. These repaired insulin producing cells can contribute to the correction and maintenance of normal physiological glycemic levels.</p> |
申请公布号 |
WO0172290(A3) |
申请公布日期 |
2002.03.14 |
申请号 |
WO2001EP03725 |
申请日期 |
2001.04.02 |
申请人 |
PROBIODRUG GESELLSCHAFT FUER ARZNEIMITTELFORSCHUNG;DEMUTH, HANS-ULRICH;GLUND, KONRAD |
发明人 |
DEMUTH, HANS-ULRICH;GLUND, KONRAD |
分类号 |
C07D277/04;A61K31/00;A61K31/40;A61K31/401;A61K31/425;A61K31/426;A61K38/00;A61K45/00;A61K45/06;A61P3/10;A61P5/50;A61P19/02;A61P29/00;A61P31/18;A61P37/06;A61P43/00;(IPC1-7):A61P3/10 |
主分类号 |
C07D277/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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