| 摘要 |
The cellular response to ultraviolet radiation exposure has been characteriz ed on the molecular level through the use of high density gene array technology . Nucleic acid molecules and protein molecules, the expression of which are repressed or induced in response to ultraviolet radiation exposure, are identified according to a temporal pattern of altered expression post ultraviolet radiation exposure. Methods are disclosed that utilized these ultraviolet radiation-regulated molecules as markers for ultraviolet radiati on exposure. Other screening methods of the invention are designed for the idenfication of compounds that modulate the response of a cell to ultraviole t radiation exposure. The invention also provides compositions useful for drug screening or pharmaceutical purposes. |
