VECTORS DERIVED FROM SOUTH AFRICAN ARBOVIRUS NO. 86
摘要
Provided herein are alphavirus vectors derived from South African Arbovirus No. 86 (S.A.AR86) comprising attenuating mutations and methods of making the same. Also provided are improved viral vectors and helper constructs comprising a S.A.AR86 capsid enhancer sequence. The present invention also provides S.A.AR86 replicon and helper constructs comprising an alphavirus capsid enhancer sequence. Further provided are methods of administering an alphavirus vector comprising a heterologous nucleotide sequence (preferably encoding an immunogen or a therapeutic polypeptide) according to the invention to a cell or subject. In preferred embodiments, the alphavirus vector delivers the heterologous nucleotide sequence to the cells of the bone, bone marrow, and/or bone-associated connective tissue.
申请公布号
WO0220721(A2)
申请公布日期
2002.03.14
申请号
WO2001US27644
申请日期
2001.09.06
申请人
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;JOHNSTON, ROBERT, E.;HEISE, MARK, T.;SIMPSON, DENNIS
发明人
JOHNSTON, ROBERT, E.;HEISE, MARK, T.;SIMPSON, DENNIS