摘要 |
<p>The present invention relates to granulocyte colony stimulating factor ('G-CSF') polypeptide analog compositions. The concept detailed herein provides methods for screening G-CSF analogs, designed with one or more substitutions to amino acids, and selecting analogs for use G-CSF replacements or antagonists, and may be generalized beyond G-CSF analogs as well. In addition, pharmaceutical compositions and methods of use are provided for analogs so selected.</p> |