NOVEL G-PROTEIN COUPLED RECEPTOR PROTEIN AND DNA THEREOF

摘要

The present invention relates to a human brain-derived protein, a partial peptide thereof or a salt thereof, a DNA encoding the receptor protein, a process for producing the protein, a method for determining a ligand for the protein, a method for screening/a kit for screening a compound which alters property of a ligand binding with the protein, a compound or a salt thereof obtainable by the screening, an antibody to the protein and the like. The human brain-derived protein or the DNA encoding the protein of the present invention are useful as or in 1 &cir& determination of a ligand, 2 &cir& obtaining of an antibody and antiserum, 3 &cir& construction of the expression system for a recombinant receptor protein, 4 &cir& development of receptor binding assay using the same expression system and screening of drug candidate compound, 5 &cir& implementation of drug design based on comparison with a ligand receptor having the structural similarity, 6 &cir& reagents for preparing a probe or a PCR primer in gene therapy, 7 &cir& production of a transgenic animal, or 8 &cir& a drug such as an agent for gene prophylaxis or therapy.