| 摘要 |
<p>There are provided an H chain polypeptide of a recombinant antibody against human TNF alpha or its fragment, having at least one of the following amino acid sequences: a) as CDR-H1, <IMAGE> 2) as CDR-H2, <IMAGE> and c) as CDR-H3, <IMAGE> an L chain polypeptide of a recombinant antibody against human TNF alpha having at least one of the following amino acid sequences: a') as CDR-L1. <IMAGE> b') as CDR-L2, <IMAGE> and c') as CDR-L3, <IMAGE> and a humanized antibody against human TNF alpha comprising the above-described H chain polypeptide or its fragment and the L chain polypeptide, or its fragment. There is further provided, a method for producing a humanized anti-TNF alpha antibody which comprises transforming host cells by an expression vector having a gene encoding the above-described antibody, etc. and culturing the cells. <IMAGE></p> |
