发明名称 |
Method for preparing (2s)-1-(2r3s)-5-chloro-3-(2-chlorophenyl) -1-(3,4-dimethoxy benzene-sulphonyl) 3-hydroxy-2,3-dihydro-1h-indole-2-carbonyl pyrrolidine-2-carboxamide |
摘要 |
An improved process for preparing (2S)-1-[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-(3,4-dimethoxybenzenesulphonyl)-3-hydroxy-2,3 -dihydro-1H-indole-2-carbonyl]pyrrolidine-2-carboxamide by cyclization of (2S)-1-{[[4-chloro-2-(2-chlorobenzoyl)phenyl]-(3,4-dimethoxybenzenesulphonyl)amino]acetyl}pyrrolidine-2-carboxamide in the presence of an alkali metal hydroxide in a mixture of polyethylene glycol and water.
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申请公布号 |
US6355809(B1) |
申请公布日期 |
2002.03.12 |
申请号 |
US20010831721 |
申请日期 |
2001.05.14 |
申请人 |
SANOFI-SYNTHELABO |
发明人 |
CHANTREUX DOMINIQUE;MERCEY PHILIPPE |
分类号 |
A61K38/00;A61P1/00;A61P9/00;A61P13/12;A61P15/00;A61P25/00;A61P35/00;C07D403/06;C07K5/065;C07K5/078;(IPC1-7):C07D209/04;C07D401/06 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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