发明名称 |
Guanosine-rich oligonucleotide integrase inhibitors |
摘要 |
A method and compositions for treating viral infection (IV) vitro and in vivo using a guanosine-rich oligonucleotide. The oligonucleotides have sufficient guanosine to form a guanosine tetrad. Also provided are oligonucleotides of at least two runs of at least two guanosines. Also provided are guanosine-rich oligonucleotides and methods for treating viral infections in humans, and a method for designing guanosine-rich oligonucleotides having anti-viral activity and integrase inhibition activity.
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申请公布号 |
US6355785(B1) |
申请公布日期 |
2002.03.12 |
申请号 |
US19990429130 |
申请日期 |
1999.10.28 |
申请人 |
ARONEX PHARMACEUTICALS, INC. |
发明人 |
RANDO ROBERT F.;FENNEWALD SUSAN;ZENDEGUI JOSEPH G.;OJWANG JOSHUA O.;HOGAN MICHAEL E.;POMMIER YVES;MAZUMDER ABHIJIT |
分类号 |
A61K38/00;C07H21/00;C12N15/113;H01L23/29;(IPC1-7):C07H21/00;C07H21/02;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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