发明名称 |
Use of a melanoma differentiation associated gene (mda-7) for inducing apoptosis of a tumor cell |
摘要 |
This invention provides a method for reversing the cancerous phenotype of a cancer cell by introducing a nucleic acid having the melanoma differentiation associated gene (mda-7) into the cell under conditions that permit the expression of the gene so as to thereby reverse the cancerous phenotype of the cell. This invention also provides a method for reversing the cancerous phenotype of a cancer cell by introducing the gene product of the above-described gene into the cancerous cell so as to thereby reverse the cancerous phenotype of the cell. This invention also provides a pharmaceutical composition having an amount of a nucleic acid having the melanoma differentiation associated gene (mda-7) or the gene product of a melanoma differentiation associated gene (mda-7) effective to reverse the cancerous phenotype of a cancer cell and a pharmaceutically acceptable carrier.
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申请公布号 |
US6355622(B1) |
申请公布日期 |
2002.03.12 |
申请号 |
US19990251124 |
申请日期 |
1999.02.16 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
FISHER PAUL B. |
分类号 |
A61K9/127;A61K31/16;A61K35/76;A61K38/17;A61K39/395;A61K48/00;A61P35/00;(IPC1-7):A01N43/04;C12Q1/68;C12P21/06 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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