摘要 |
Piperazinedione compounds of the formula: Each of <custom-character file="US20020028819A1-20020307-P00900.TIF" wi="20" he="20" id="custom-character-00001"/>and <custom-character file="US20020028819A1-20020307-P00901.TIF" wi="20" he="20" id="custom-character-00002"/>, independently, is a single bond or a double bond; A is H or CH(RaRb) when <custom-character file="US20020028819A1-20020307-P00900.TIF" wi="20" he="20" id="custom-character-00003"/>is a single bond, or C(RaRb) when <custom-character file="US20020028819A1-20020307-P00901.TIF" wi="20" he="20" id="custom-character-00004"/>is a double bond; Z is R3O-(Ar)-B, in which B is CH(Rc) when <custom-character file="US20020028819A1-20020307-P00901.TIF" wi="20" he="20" id="custom-character-00005"/>is a single bond, or C(Rc) when <custom-character file="US20020028819A1-20020307-P00901.TIF" wi="20" he="20" id="custom-character-00006"/>is a double bond; Ar is heteroaryl; and R3 is H, alkyl, aryl, heteroaryl, C(O)Rd, C(O)ORd, C(O)NRdRe, or SO2Rd; each of R1 and R2, independently, is H, C(O)Rd, C(O)ORd, C(O)NRdRe, or SO2Rd; and each of Ra, Rb, Rc, Rd, and Re, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl. Optionally, Ra and Rb taken together are cyclyl or heterocyclyl; and, also optionally, R1 and Ra or R1 and Rb taken together are cyclyl or heterocyclyl.
|