发明名称 |
Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
摘要 |
The present invention describes pyridazinone compounds of formula I which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important "housekeeping" enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectivity of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs)
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申请公布号 |
US2002028938(A1) |
申请公布日期 |
2002.03.07 |
申请号 |
US20010870838 |
申请日期 |
2001.05.31 |
申请人 |
BLACK LAWRENCE A.;BASHA ANWER;KOLASA TEODOZYJ;KORT MICHAEL E.;LIU HUAQING;MCCARTY CATHERINE M.;PATEL MEENA;ROHDE JEFFREY J.;COGHLAN MICHAEL J.;STEWART ANDREW O. |
发明人 |
BLACK LAWRENCE A.;BASHA ANWER;KOLASA TEODOZYJ;KORT MICHAEL E.;LIU HUAQING;MCCARTY CATHERINE M.;PATEL MEENA;ROHDE JEFFREY J.;COGHLAN MICHAEL J.;STEWART ANDREW O. |
分类号 |
C07D237/14;C07D405/04;C07D409/04;(IPC1-7):C0743/02 |
主分类号 |
C07D237/14 |
代理机构 |
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地址 |
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