Crystallisierung vom Alpha-L-Aspartyl-L-phenylalanylmethylester aus wässrigen Lösungen

摘要

A method for crystallizing aspartame comprising the combination of steps of: (A) providing (i) dispersed droplets of a fluid mixture comprising aspartame and water, and (ii) a water-immiscible fluid zone; (B) passing the dispersed droplets through the water-immiscible fluid zone under effective temperature and dispersive conditions to effect cooling of the dispersed droplets so that a state of initial relative supersaturation of aspartame between about 1 and 6 is formed within the dispersed droplets; (C) collecting the dispersed droplets in the supersaturated state in a substantially static collection zone so that a slurry comprising a crystalline form of aspartame is formed from the droplets. The method provides for rapid, efficient cooling of aspartame solutions and yields aspartame crystals with desirable qualities.