GENE CALLED ALADIN, INVOLVED IN ALLGROVE SYNDROME, ITS EXPRESSION PRODUCT AND THEIR APPLICATIONS

摘要

The present invention relates to the identification of a novel gene, called ALADIN involved in Allgrove syndrome, and of the ALADIN gene products, as well as to the diagnostic and therapeutic applications thereof. More particularly, the invention relates to a method of in vitro diagnosis of a disorder of Allgrove syndrome's family, wherein either one or more mutation(s) is detected in the ALADIN gene, or an abnormal expression of ALADIN gene product is detected.