发明名称 |
PROCESS FOR PREPARING PHARMACEUTICAL COMPOSITIONS FOR USE WITH SOFT GELATIN FORMULATIONS |
摘要 |
The invention disclosed herein is a process for increasing the achievable concentration of a pharmaceutically active ingredient relative to fill composition viscosity for dosage units. The process is particularly useful i n the preparation of soft gelatin capsules containing ibuprofen, naproxen, indomethacin, and acetaminophen, as the pharmaceutically active ingredient. As a result of the process, lesser quantities of composition ingredients other than the pharmaceutically active ingredient are needed to accomplish the sam e therapeutically effective dosage, thereby significantly increasing the concentration of the pharmaceutically active ingredient resulting in either a reduction in overall fill volume and dosage unit size or an increase in concentration of pharmaceutically active ingredient per dosage form.
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申请公布号 |
CA2419993(A1) |
申请公布日期 |
2002.03.07 |
申请号 |
CA20012419993 |
申请日期 |
2001.08.28 |
申请人 |
R.P. SCHERER TECHNOLOGIES, INC. |
发明人 |
LEWIS, JACQUELINE CAROL;WEBSTER, CHRISTOPHER CLIVE;FERDINANDO, JOSEPHINE CHRISTINE;TINDAL, STEPHEN CHARLES |
分类号 |
A61K47/34;A61K9/48;A61K31/167;A61K31/192;A61K31/405;A61K45/00;A61K47/02;(IPC1-7):A61K45/06 |
主分类号 |
A61K47/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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